Prognostic Value of T-Wave Alternans in Patients With Heart Failure Due to Nonischemic Cardiomyopathy
نویسنده
چکیده
Results Patients with abnormal TWA (65%) compared with normal TWA (35%) tests were older (60 13 years vs. 57 12 years), were more frequently in NYHA functional class III (22% vs. 19%), and had a modestly lower LVEF (29 7% vs. 31 7%). Primary end point rates in patients with abnormal and normal TWA tests were 6.5% (95% confidence interval [CI] 4.5% to 9.4%) and 1.6% (95% CI 0.6% to 4.4%), respectively. Unadjusted and adjusted hazard ratios were 4.0 (95% CI 1.4% to 11.4%; p 0.002) and 3.2 (95% CI 1.1% to 9.2%; p 0.013), respectively. Hazard ratios for total mortality and for arrhythmic death life-threatening arrhythmias were 4.6 (p 0.002) and 5.5 (p 0.004), respectively; 18-month negative predictive values for the 3 end points ranged between 97.3% and 98.6%.
منابع مشابه
Onset heart rate of microvolt-level T-wave alternans provides clinical and prognostic value in nonischemic dilated cardiomyopathy.
OBJECTIVES This study was designed to determine the prognostic value of onset heart rate (OHR) in T-wave alternans (TWA) in patients with nonischemic dilated cardiomyopathy (DCM). BACKGROUND One of the current major issues in DCM is to prevent sudden cardiac death (SCD). However, the value of the OHR of TWA as a prognostic indicator in DCM remains to be elucidated. METHODS We prospectively ...
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OBJECTIVES The objective of this study was to perform a meta-analysis of the predictive value of microvolt T-wave alternans (MTWA) testing for arrhythmic events in a wide variety of populations. BACKGROUND Previous studies describing the use of MTWA as a predictor of ventricular tachyarrhythmic events have been limited by small sample sizes and disparate populations. METHODS Prospective studies...
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Sudden cardiac death remains one of the leading causes of death in Europe and the United States. Accordingly, the ability to identify patients at high risk of sudden cardiac death is important so that appropriate treatments can be used efficiently. Recently, T wave alternans (TWA) has emerged as a promising new test for such risk stratification. TWA is a heart rate dependent measure of arrhythm...
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